IgA NEPHROPATHY MOD VIDEO
There may be a hidden culprit in IgA Nephropathy: the gut
IgA Nephropathy is thought to primarily originate in the ileum.1
See the role the gut plays in IgA Nephropathy
![iga-nephropathy-mucosal-surfaces](/sites/default/files/2021-11/iga-nephropathy-mucosal-surfaces_1.jpg)
![characters-source_2](/sites/default/files/2021-11/characters-source_2.png)
~33%
of patients with IgA Nephropathy will experience recurrence of the disease after kidney transplantation, indicating that the source of disease is extrarenal in origin.14,15
IgA NEPHROPATHY MECHANISM OF DISEASE
![iga-nephropathy-mucosal-surfaces](/sites/default/files/2022-09/nephropathy_one.jpg)
IgA Nephropathy, or IgAN, is an autoimmune disease that affects the kidneys, but may begin in the gut. The Gut-Kidney-Axis may play a defining role in IgAN.1,16
![iga1-mucosal-tissue](/sites/default/files/2022-09/nephropathy_two.jpg)
Mucosal IgA1 has a poorly-galactosylated hinge region, and is often secreted as a dimer.1,17
![peyers patches iga nephropathy if we cannot do](/sites/default/files/2022-09/nephropathy_three.jpg)
Gut associated lymphoid tissue (GALT) contains specialised lymphoid tissues, including Peyer's patches, which are concentrated in the distal ileum. These provide immune surveillance, including producing mucosal type IgA1.1,18
![immune-complex-iga-nephropathy](/sites/default/files/2022-09/nephropathy_four.jpg)
Systemic IgA and IgG autoantibodies react to the galactose-deficient mucosal IgA1 hinge region, forming immune complexes.17,19
![renal-function-deterioration-iga-nephropathy](/sites/default/files/2022-09/nephropathy_five.jpg)
The circulating complexes deposit in the kidney glomerular mesangium, where they become trapped and mucosal IgA binds to extracellular matric components.17,20
This autoimmune response leads to glomerular and tubulo-interstitial injury, resulting in proteinuria and a progressive decline in renal function.21
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![kedney-information-iga-nephropathy](/sites/default/files/2022-09/kidney-information-iga-nephropathy_1_1.png)